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	Provedor de dados Genet. Mol. Biol. (2) Autor Coura,Renata dos Santos (2) Cabello,Pedro Hernan (1) Hatagima,Ana (1) Koifman,Rosalina J. (1) Koifman,Sergio (1) Marques,Christiane de Fátima Silva (1) Nardi,Nance Beyer (1) Mais... Palavra-chave AAV-based recombinant vectors (1) Adeno-associated virus (1) Brazil (1) CYP1A1 (1) CYP2E1 (1) Cytochromes P450 (1) Gene therapy (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2008 (1) 2007 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última A role for adeno-associated viral vectors in gene therapy Genet. Mol. Biol. Coura,Renata dos Santos; Nardi,Nance Beyer. Gene therapy constitutes a therapeutic intervention based on modification of the genetic material of living cells, by correcting genetic defects or overexpressing therapeutic proteins. The success of gene therapy protocols depends on the availability of therapeutically suitable genes, appropriate gene delivery systems and proof of safety and efficacy. Recent advances on the development of gene delivery systems, particularly on viral vectors engineering and improved gene regulatory systems, have led to marked progress in this field. Although the available vector systems can successfully transfer genes into cells, the ideal delivery vehicle has not been found. In this context, adeno-associated virus vectors (AAV) are arising as a promising tool for a wide... Tipo: Info:eu-repo/semantics/article Palavras-chave: Adeno-associated virus; AAV-based recombinant vectors; Gene therapy. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000100001 CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population Genet. Mol. Biol. Coura,Renata dos Santos; Marques,Christiane de Fátima Silva; Koifman,Rosalina J.; Koifman,Sergio; Cabello,Pedro Hernan; Hatagima,Ana. The enzymes encoded by the polymorphic genes CYP1A1 and CYP2E1 play an important role in the activation and inactivation of xenobiotics. These enzymes have been associated with xenobiotic-induced diseases, such as cancer, therapeutic failure and adverse effects of drugs. The aim of the present study was to determine the allelic and genotypic frequencies of these polymorphisms in a large, ethnically mixed Brazilian population sample from Rio de Janeiro. Polymorphisms CYP1A1 and CYP2E1 were determined in 870 unrelated individuals by PCR-RFLP analysis in peripheral blood DNA. The observed allelic frequencies were 0.90 for CYP1A1*1A and 0.95 for CYP2E1*1A, in the total sample. The allelic frequency of CYP1A1*2C in "pardos" (0.13) and Brazilian whites (0.11)... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cytochromes P450; CYP1A1; CYP2E1; Brazil. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000100001 Registros recuperados: 2 Primeira ... 1 ... Última

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